Examples Of Curcumin Clarifying Its Defense Against Cancer
Many studies have been conducted on the various examples of curcumin. These are supplements that have incredible pharmaceutical benefits. A lot of these studies suggest curcumin may be useful for the prevention and treatment of numerous diseases.
A great example is curcumin’s use in oncology, in Weill Medical College and in New York Presbyterian Hospital. It is reported that curcumin, which is a curcuminoid originating in turmeric, directly repressed the COX-2 enzyme according to Zhang et al. 1999. Many different oncologists are very excited about curcumin being such a potent anti-inflammatory substance. It is classified as a prospective third generation chemo-preventive agent for cancer.
Curcumin is illustrative of its defense against cancer, is its capability of inhibiting chemically stimulate carcinogenesis in the colon, while being administered at various stages of cancer progression. When laboratory rats were given curcumin at an initial stage or delayed and given in the premalignant phase, the rats had a smaller occurrence and less statistics of all-encompassing malignant tumors of the colon. (Kawamori et al. 1999). Also, as a result of inhibiting the acid interactions of COX-2-arachidonic, curcumin curbs prostaglandins which are to blame for inflammatory progressions. (Plummer et al. 1999). Continual inflammation has been considered as a reason for having colon cancer, for many years. (Konig et al. 1976).
Examples of curcumin healing in antioxidant action are the slowing down, or reversing of the oxidative damage. It does this by searching for and counteracting the free radicals. By resolving the superoxide and hydroxyl radicals and the infringement on the oxidative chain, it causes these reactions. Curcumin shields DNA with superior efficiency over Vitamin E, beta-carotene or lipoic acid (Ruby et al. 1995; Li et al. 2001; Ahsan et al. 1999).
More examples deal with breast cancer. Curcumin inhibits the increase of various cell lines of breast cancer (Inano et al. 1999), mainly those that are a consequence of environmental exposure to chemical and pesticide estrogens (Verma et al. 1998). In addition, estrogen, curcumin, and estrogen impersonators get entry into the cells by way of the aryl hydrocarbon receptor. Since curcumin contends for entry, it can assist in crowding out the harmful materials (Ciolino et al. 1998).
At concentrations as small as 3.5 mcg/mL, curcumin provoked apoptotic cell death in promyelocytic leukemia HL-60 cells (Kuo et al. 1996).
Studies have shown examples of curcumin helping with prostate cancer. Curcumin has the ability to diminish the proliferative prospect of androgen-independent cancer cells in the prostate, plus cells of additional androgen-dependent cancers. This is done mainly by the encouragement of apoptosis. Furthermore, a considerable decline in microvessel density, which is the supporting blood supply of tumors, was observed (Dorai et al. 2001).